zingerone

Modify Date: 2024-01-02 19:44:34

zingerone structure	Common Name	zingerone
	CAS Number	122-48-5	Molecular Weight	194.227
	Density	1.1±0.1 g/cm3	Boiling Point	323.0±27.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₄O₃	Melting Point	40-41 °C(lit.)
	MSDS	Chinese USA	Flash Point	123.7±17.2 °C

Use of zingerone

Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3].

Name	zingerone
Synonym	More Synonyms

Description	Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Natural Products >> Phenols
Target	NF-κB[3]
In Vitro	Zingerone is a nontoxic methoxyphenol with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic properties[1]. Zingerone (0-2 mM) decreases neruoblastoma cell survival[3]. Zingerone (0-2 mM) reduces cyclin D1 expression, increases cleavage of caspase-3 and PARP-1 in BE(2)-M17 cells[3].
In Vivo	Zingerone (50, 100  mg/kg, p.o. daily for 21 days) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation in rat[2]. Zingerone (10 mg/kg, i.p.) inhibits tumor progression through mitotic arrest, failure of cell division, and stimulation of apoptosis[3].
References	[1]. Ahmad B, et al. A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone). ScientificWorldJournal. 2015;2015:816364. [2]. Ahmad B, et al. Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: Probable role of NF-kB activation. Saudi Pharm J. 2018 Dec;26(8):1137-1145. [3]. Choi JS, et al. Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest. Int J Mol Sci. 2018 Sep 19;19(9).

Density	1.1±0.1 g/cm3
Boiling Point	323.0±27.0 °C at 760 mmHg
Melting Point	40-41 °C(lit.)
Molecular Formula	C₁₁H₁₄O₃
Molecular Weight	194.227
Flash Point	123.7±17.2 °C
Exact Mass	194.094299
PSA	46.53000
LogP	0.64
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.526
Storage condition	2-8°C

zingerone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL8900000

CHEMICAL NAME :: 2-Butanone, 4-(4-hydroxy-3-methoxyphenyl)-

CAS REGISTRY NUMBER :: 122-48-5

BEILSTEIN REFERENCE NO. :: 2051099

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H14-O3

MOLECULAR WEIGHT :: 194.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,851,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2580 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,851,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,851,1982

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	EL8900000
Packaging Group	II; III
Hazard Class	4.1
HS Code	29333999

Precursor 8
CAS#:1080-12-2 4-(4-hydroxy-3-... CAS#:121-33-5 Vanillin CAS#:78-94-4 Methyl vinyl ketone CAS#:90-05-1 Guaiacol
CAS#:61152-59-8 4-hydroxy-4-(4-... CAS#:39886-78-7 4-(4-(Benzyloxy... CAS#:458-36-6 coniferyl aldehyde CAS#:290820-47-2 (2E)-3-[4-[[ter...
DownStream 7
CAS#:39728-80-8 4-(3-hydroxybut... CAS#:77334-06-6 1-(4-hydroxy-3-... CAS#:77398-90-4 5-hydroxy-1-(4-... CAS#:56700-87-9 4-[3-Methoxy-4-...
CAS#:61152-58-7 4-(3-hydroxybut... CAS#:61152-62-3 4-(3,4-Dihydrox... CAS#:6302-60-9 2-Butanone,4-(3...

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 368-78, (2013)

Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of th...

Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells.

BMC Complement Altern. Med. 12 , 202, (2012)

Drugs used both in classical chemotherapy and the more recent targeted therapy do not have cancer cell specificity and, hence, cause severe systemic side effects. Tumors also develop resistance to suc...

Targeting antioxidative signal transduction and stress response system: control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function.

J. Appl. Microbiol. 101(1) , 181-9, (2006)

The aim of this study was to show whether antioxidative response systems are potentially useful molecular targets for control of Aspergillus fumigatus and Aspergillus flavus. Selected phenolic agents ...

UNII-4MMW850892

Vanillyl acetone

4-(4-Hydroxy-3-methoxyphenyl)-2-butanone

4-(4-hydroxy-3-methoxyphenyl)butan-2-one

Zingiberone

2-Butanone, 4-(4-hydroxy-3-methoxyphenyl)-

EINECS 204-548-3

Vanillylacetone

MFCD00048232

3-Methoxy-4-hydroxybenzylacetone

2-Butanone, 4- (4-hydroxy-3-methoxyphenyl)-

Zingberone

zingerone

Shanghai Nianxing Industrial Co., Ltd
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Product Name: zingerone
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China
Product Name: zingerone
Price: ￥638.0/20mg ￥118.0/5g ￥338.0/25g
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DC Chemicals Limited
China
Product Name: Zingerone
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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