DBPR112

Modify Date: 2024-01-16 18:03:59

DBPR112 Structure
DBPR112 structure
Common Name DBPR112
CAS Number 1226549-49-0 Molecular Weight 533.62
Density N/A Boiling Point N/A
Molecular Formula C32H31N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DBPR112


DBPR112 (compound 78) is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 has significant antitumor efficacy[1].

 Names

Name DBPR112

 DBPR112 Biological Activity

Description DBPR112 (compound 78) is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 has significant antitumor efficacy[1].
Related Catalog
Target

EGFRWT:15 nM (IC50)

EGFRL858R/T790M:48 nM (IC50)

References

[1]. Lin SY, et al. Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. J Med Chem. 2019 Sep 27.

 Chemical & Physical Properties

Molecular Formula C32H31N5O3
Molecular Weight 533.62