Azelaic acid

Modify Date: 2024-01-02 15:21:22

Azelaic acid Structure
Azelaic acid structure
 Common Name Azelaic acid
CAS Number 123-99-9 Molecular Weight 188.221
Density 1.1±0.1 g/cm3 Boiling Point 286 ºC (100 mmHg)
Molecular Formula C9H16O4 Melting Point 98-103 ºC
MSDS Chinese USA Flash Point 215 ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Azelaic acid


Azelaic acid is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners.

 Names

Name azelaic acid
Synonym More Synonyms

 Azelaic acid Biological Activity

Description Azelaic acid is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Jung HW, et al. Priming in systemic plant immunity. Science. 2009 Apr 3;324(5923):89-91.

[2]. Liu RH, et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol. 2006 Aug;142(8):1047-52.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 286 ºC (100 mmHg)
Melting Point 98-103 ºC
Molecular Formula C9H16O4
Molecular Weight 188.221
Flash Point 215 ºC
Exact Mass 188.104858
PSA 74.60000
LogP 1.33
Vapour density 6.5 (vs air)
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.475
Stability Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.
Water Solubility 2.4 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CM1980000
CHEMICAL NAME :
Azelaic acid
CAS REGISTRY NUMBER :
123-99-9
BEILSTEIN REFERENCE NO. :
1101094
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C9-H16-O4
MOLECULAR WEIGHT :
188.25
WISWESSER LINE NOTATION :
QV7VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A067-313 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83495 No. of Facilities: 170 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 1676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83495 No. of Facilities: 3427 (estimated) No. of Industries: 35 No. of Occupations: 42 No. of Employees: 34469 (estimated) No. of Female Employees: 7576 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS CM1980000
HS Code 2917139000

 Synthetic Route

 Customs

HS Code 2917139000
Summary 2917139000 azelaic acid, sebacic acid, their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles86

More Articles
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

 Synonyms

Skinoren
AZALEIC ACID
Azelaate
3,4-Dimethoxybenzaldehyde
Nonanedioic acid
Azelaic acid
UNII-F2VW3D43YT
AZELAIC ACID/NONANEDIOIC ACID
Barasertib
AZELAIC ACID FOR SYNTHESIS
INH 34
Azelex
Azelaicacid
Finaceae
lepargylic acid
1,7-HEPTANE DICARBONIC ACID
1,7-HEPTANEDICARBOXYLIC
AZD1152-HQPA
Azelainic acid
HEPTANE-1,7-DICARBOXYLIC ACID
Azalaic Acid
AZELAIC ACID( MICRONIZED )
EINECS 204-669-1
anchoic acid
1,7-Heptanedicarboxylic acid
MFCD00004432
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Related Compounds: More...
Azelaic acid
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azelaic acid aldehyde
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azelaic acid methyl ester
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azelaic acid monochloride
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Azelaic acid,dioctyl ester
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Azelaic acid,diethyl ester
624-17-9
Azelaic acid,dihexyl ester
109-31-9
Azelaic acid,dibutyl ester
2917-73-9
azelaic acid dimethyl ester
1732-10-1
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Imidazo[1,5-a]pyrazine-1-carboxamide,5,6,7,8-tetrahydro-n,3-diphenyl-
1094085-75-2
2-(dimethylamino)-N-methoxy-N-methylisonicotinamide
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3-(Methyl((4-methylthiazol-2-yl)methyl)carbamoyl)benzoic acid
913073-57-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
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