Menaquinone 4-d7

Modify Date: 2024-01-12 11:36:27

Menaquinone 4-d7 Structure
Menaquinone 4-d7 structure
Common Name Menaquinone 4-d7
CAS Number 1233937-25-1 Molecular Weight 451.691
Density 1.0±0.1 g/cm3 Boiling Point 570.6±50.0 °C at 760 mmHg
Molecular Formula C31H33D7O2 Melting Point N/A
MSDS N/A Flash Point 208.3±27.1 °C

 Use of Menaquinone 4-d7


Menaquinone-4-d7 (Vitamin K2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

 Names

Name Menaquinone 4-d7
Synonym More Synonyms

 Menaquinone 4-d7 Biological Activity

Description Menaquinone-4-d7 (Vitamin K2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Noda S, et al. Menaquinone-4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells. Nutr Res. 2016 Nov;36(11):1269-1276.

[3]. Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 570.6±50.0 °C at 760 mmHg
Molecular Formula C31H33D7O2
Molecular Weight 451.691
Flash Point 208.3±27.1 °C
Exact Mass 451.346771
LogP 10.94
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.539

 Synonyms

Menaquinone-4-(5,6,7,8-d4,2-methyl-d3)
Menaquinone 4-d7
1,4-Naphthalenedione-5,6,7,8-d4, 2-(methyl-d3)-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-
2-(2H3)Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-(2H4)naphthalenedione