spermidine

Modify Date: 2024-01-02 14:59:10

spermidine Structure
spermidine structure
Common Name spermidine
CAS Number 124-20-9 Molecular Weight 145.246
Density 0.9±0.1 g/cm3 Boiling Point 246.6±8.0 °C at 760 mmHg
Molecular Formula C7H19N3 Melting Point 23-25 °C
MSDS Chinese USA Flash Point 118.1±22.0 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of spermidine


Spermidine, a precursor of spermine, is a polyamine derived from putrescine and could help stabilize some membranes and nucleic acid structures.

 Names

Name spermidine
Synonym More Synonyms

 spermidine Biological Activity

Description Spermidine, a precursor of spermine, is a polyamine derived from putrescine and could help stabilize some membranes and nucleic acid structures.
Related Catalog
Target

Human Endogenous Metabolite

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 246.6±8.0 °C at 760 mmHg
Melting Point 23-25 °C
Molecular Formula C7H19N3
Molecular Weight 145.246
Flash Point 118.1±22.0 °C
Exact Mass 145.157898
PSA 64.07000
LogP -0.84
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.475
Storage condition 2-8°C
Stability Stable, but air-sensitive and very hygroscopic - store under argon. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.
Water Solubility H2O: 1 M at 20 °C, clear, colorless

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EJ7000000
CHEMICAL NAME :
1,4-Butanediamine, N-(3-aminopropyl)-
CAS REGISTRY NUMBER :
124-20-9
BEILSTEIN REFERENCE NO. :
1698591
LAST UPDATED :
199706
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C7-H19-N3
MOLECULAR WEIGHT :
145.29
WISWESSER LINE NOTATION :
Z4M3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD30 - Lethal Dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD30 - Lethal Dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
78 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
9504 gm/kg/14D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lung
DOSE/DURATION :
200 mmol/L
REFERENCE :
IJRBA3 International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1959- Volume(issue)/page/year: 9,185,1965

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive;
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 2735 8/PG 2
WGK Germany 3
RTECS EJ7000000
Packaging Group III
Hazard Class 8
HS Code 2921290000

 Synthetic Route

 Customs

HS Code 2921290000
Summary 2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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 Synonyms

spermidine
N-(γ-aminopropyl)tetramethylenediamine
N-(3-Aminopropyl)butan-1,4-diamin
N'-(3-aminopropyl)butane-1,4-diamine
1,8-Diamino-4-azaoctane (N-(3-Aminopropyl)-1,4-diaminobutane
Additive Screening
N1-(3-Aminopropyl)butane-1,4-diamine
N-(3-Aminopropyl)-4-aminobutylamine
N-(3-Aminopropyl)butane-1,4-diamine
MFCD00008229
1,4-Butanediamine, N-(3-aminopropyl)-
N-(3-Aminopropyl)-1,4-butanediamine
N-(g-Aminopropyl)tetramethylenediamine
EINECS 204-689-0
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