CP21R7

Modify Date: 2024-01-02 17:55:13

Use of CP21R7

CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.

Name	3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione
Synonym	More Synonyms

Description	CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.
Related Catalog	Research Areas >> Cancer
Target	GSK-3β:1.8 nM (IC50) PKCα:1900 nM (IC50)
In Vitro	CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM[1]. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm[2].
References	[1]. Gong L, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6. [2]. Patsch C, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003.

3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-

CP21R7

CP21

CP-21R7

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Price: $92/10mM*1mLinDMSO

Reference only. check more CP21R7 price

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