Althiomycin

Modify Date: 2024-04-05 09:09:00

Althiomycin Structure
Althiomycin structure
Common Name Althiomycin
CAS Number 12656-40-5 Molecular Weight 439.46600
Density 1.72g/cm3 Boiling Point N/A
Molecular Formula C16H17N5O6S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Althiomycin


Althiomycin, also known as matamycin, is a thiazole antibiotic, effective against Gram-positive and Gram-negative bacteria. Isolated from Streptomyces matensis, Althiomycin was first described by Margalith et al. in 1959. It acts a protein synthesis inhibitor and its site of action is the 50S subunit of the bacterial ribosome.

 Names

Name 4-Thiazolecarboxamide, N-[1-[4-[(2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl)carbonyl]-4,5-dihydro-2-thiazolyl]-2-hydroxyethyl]-2-[(hydroxyimino)methyl]
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.72g/cm3
Molecular Formula C16H17N5O6S2
Molecular Weight 439.46600
Exact Mass 439.06200
PSA 207.32000
Index of Refraction 1.768

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ3500000
CHEMICAL NAME :
4-Thiazolecarboxamide, N-(1-(4-((2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl) carbonyl)-4,5- dihydro-2-thiazolyl)-2-hydroxyethyl)-2-((hydroxyimino )methyl)-
CAS REGISTRY NUMBER :
12656-40-5
LAST UPDATED :
198211
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H17-N5-O6-S2
MOLECULAR WEIGHT :
439.50
WISWESSER LINE NOTATION :
T5N CSJ B1UNQ EVMY1Q- BT5N CSJ EV- AT5NV EHJ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,122,1967

 Synonyms

Matamycin
116-A
althiomycin
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