Arbutamine

Modify Date: 2024-01-05 03:09:19

Arbutamine Structure
Arbutamine structure
Common Name Arbutamine
CAS Number 128470-16-6 Molecular Weight 317.38000
Density 1.262g/cm3 Boiling Point 578.3ºC at 760mmHg
Molecular Formula C18H23NO4 Melting Point N/A
MSDS N/A Flash Point 195.1ºC

 Use of Arbutamine


Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases heart rate, cardiac contractility, and systolic blood pressure[1]. Arbutamine is a catecholamine for a pharmacological cardiac stress agen[2].

 Names

Name arbutamine
Synonym More Synonyms

 Arbutamine Biological Activity

Description Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases heart rate, cardiac contractility, and systolic blood pressure[1]. Arbutamine is a catecholamine for a pharmacological cardiac stress agen[2].
Related Catalog
Target

β-adrenoceptor[1]

In Vivo Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg).
References

[1]. Ruiz M, et al. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. J Nucl Med. 2002 May;43(5):664-70.

[2]. Nagarajan R, et al. A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent. Cardiovasc Drugs Ther. 1996 Mar;10(1):31-8.

 Chemical & Physical Properties

Density 1.262g/cm3
Boiling Point 578.3ºC at 760mmHg
Molecular Formula C18H23NO4
Molecular Weight 317.38000
Flash Point 195.1ºC
Exact Mass 317.16300
PSA 92.95000
LogP 2.84020

 Synonyms

4-[(1R)-1-Hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]-1,2-b enzenediol
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