1,8-Naphtholactam

Modify Date: 2024-01-02 15:12:46

1,8-Naphtholactam Structure
1,8-Naphtholactam structure
Common Name 1,8-Naphtholactam
CAS Number 130-00-7 Molecular Weight 169.179
Density 1.3±0.1 g/cm3 Boiling Point 234.7±7.0 °C at 760 mmHg
Molecular Formula C11H7NO Melting Point 173-178 °C(lit.)
MSDS Chinese USA Flash Point 128.9±3.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name Benz[cd]indol-2(1H)-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 234.7±7.0 °C at 760 mmHg
Melting Point 173-178 °C(lit.)
Molecular Formula C11H7NO
Molecular Weight 169.179
Flash Point 128.9±3.1 °C
Exact Mass 169.052765
PSA 32.86000
LogP 1.96
Vapour Pressure 0.1±0.5 mmHg at 25°C
Index of Refraction 1.724

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE3202000
CHEMICAL NAME :
Benz(cd)indol-2(1H)-one
CAS REGISTRY NUMBER :
130-00-7
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C11-H7-N-O
MOLECULAR WEIGHT :
169.19
WISWESSER LINE NOTATION :
T566 1A L CMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 50,1888,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),82,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 mg/kg/14D-I
TOXIC EFFECTS :
Liver - liver function tests impaired Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),82,1986

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS DE3202000
HS Code 2925190090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles2

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Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.

ACS Med. Chem. Lett. 1(7) , 355-359, (2010)

Mycobacterium protein tyrosine phosphatase B (mPTPB) is an essential virulence factor required for Mycobacterium tuberculosis (Mtb) survival in host macrophages. Consequently, mPTPB represents an exci...

Benz[cd]indol-2(1H)-one at 298 and 100 K.

Acta Crystallogr. C 68(Pt 1) , o1-6, (2012)

Weakly diffracting crystals of benz[cd]indol-2(1H)-one (naphtholactam), C(11)H(7)NO, were unsuitable for data collection by early photographic methods. However, a diffractometer data set collected at ...

 Synonyms

1,8-Naphtholactam
Benz[cd]indol-2(1H)-one
MFCD00009748
Naphthostyril
Benzo[cd]indol-2(1H)-one
EINECS 204-973-4
1H-benzo[cd]indol-2-one
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