beryllium oxide

MOLECULAR FORMULA :

Be-O

MOLECULAR WEIGHT :

25.01

WISWESSER LINE NOTATION :

BE O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

28 mg/m3/17W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :

IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 40,23,1971

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intratracheal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

75 mg/kg/15W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :

FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu, Fukuoka-shi, Fukuoka, Japan) V.33- 1940- Volume(issue)/page/year: 71,19,1980

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

17 mg/m3/5H/D/48W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Musculoskeletal - tumors

REFERENCE :

AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 51,473,1951

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

500 mg/kg/6W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Musculoskeletal - tumors

REFERENCE :

FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,221,1946

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Implant

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

10 mg/kg

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Musculoskeletal - tumors

REFERENCE :

ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 88,89,1969

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

500 mg/kg/48W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Musculoskeletal - tumors

REFERENCE :

PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 2,203,1961

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Intratracheal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

169 mg/kg/2W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - chronic pulmonary edema Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 19,190,1959

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

625 mg/kg/25W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Musculoskeletal - tumors

REFERENCE :

AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-30, 1951-82. Volume(issue)/page/year: 25,99,1977

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Intratracheal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

79 mg/kg/15W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :

SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 20,230,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intratracheal

DOSE :

139 mg/kg

SEX/DURATION :

female 3 day(s) after conception

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(8),44,1986 *** REVIEWS *** ACGIH TLV-SUSPECTED HUMAN CARCINOGEN 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997 ACGIH TLV-TWA 0.002 mg(Be)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,17,1972 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,143,1980 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 IARC Cancer Review:Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 6,497,1973 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-POLAND:TWA 0.001 mg(Be)/m3 JAN 1993 OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993 OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3577 No. of Facilities: 66 (estimated) No. of Industries: 6 No. of Occupations: 9 No. of Employees: 4305 (estimated) No. of Female Employees: 849 (estimated)