Citarinostat

Modify Date: 2024-01-14 11:59:22

Citarinostat Structure
Citarinostat structure
Common Name Citarinostat
CAS Number 1316215-12-9 Molecular Weight 467.948
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C24H26ClN5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Citarinostat


Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.IC50 value: 4 nM (HDAC6), 76 nM (HDAC3)Target: HDACThe detailed information please refer to WO2015061684A1 and 2015054197A1.

 Names

Name Citarinostat
Synonym More Synonyms

 Citarinostat Biological Activity

Description Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.IC50 value: 4 nM (HDAC6), 76 nM (HDAC3)Target: HDACThe detailed information please refer to WO2015061684A1 and 2015054197A1.
Related Catalog
Target

HDAC6:2.6 nM (IC50)

HDAC1:35 nM (IC50)

HDAC2:45 nM (IC50)

HDAC3:46 nM (IC50)

HDAC8:137 nM (IC50)

HDAC7:7300 nM (IC50)

References

[1]. Huang P, et al. Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models. Oncotarget. 2017 Jan 10;8(2):2694-2707.

[2]. From PCT Int. Appl. (2015), WO 2015054197 A1 20150416.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C24H26ClN5O3
Molecular Weight 467.948
Exact Mass 467.172424
PSA 107.45000
LogP 1.80
Index of Refraction 1.624
Storage condition -20℃

 Synonyms

2-[(2-Chlorophenyl)(phenyl)amino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
Citarinostat
2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxohepl)pyrimidine-5-carboxamide
5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-
2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide
ACY-241
UNII:441P620G3P
ACY-241 Avi Tini
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Price: ¥873.6/5mg

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