1-(2H9)Pyrenol

Modify Date: 2024-01-21 16:30:15

1-(2H9)Pyrenol Structure
1-(2H9)Pyrenol structure
Common Name 1-(2H9)Pyrenol
CAS Number 132603-37-3 Molecular Weight 227.305
Density 1.4±0.1 g/cm3 Boiling Point 437.4±14.0 °C at 760 mmHg
Molecular Formula C16HD9O Melting Point 165-168ºC
MSDS N/A Flash Point 213.0±12.0 °C

 Use of 1-(2H9)Pyrenol


1-Hydroxypyrene-d9 is the deuterium labeled 1-Hydroxypyrene[1]. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[2].

 Names

Name 1-Hydroxypyrene-d9
Synonym More Synonyms

 1-(2H9)Pyrenol Biological Activity

Description 1-Hydroxypyrene-d9 is the deuterium labeled 1-Hydroxypyrene[1]. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Fernando Freitas, et al. Urinary 1-hydroxypyrene Is Associated With Oxidative Stress and Inflammatory Biomarkers in Acute Myocardial Infarction. Int J Environ Res Public Health  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 437.4±14.0 °C at 760 mmHg
Melting Point 165-168ºC
Molecular Formula C16HD9O
Molecular Weight 227.305
Flash Point 213.0±12.0 °C
Exact Mass 227.129654
PSA 20.23000
LogP 4.43
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.895

 Synonyms

(H)Pyren-1-ol
1-(H)Pyrenol
1-Pyren-d-ol
2,3,4,5,6,7,8,9,10-nonadeuteriopyren-1-ol