ASS234
Modify Date: 2024-04-05 12:36:58
ASS234 structure
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Common Name | ASS234 | ||
|---|---|---|---|---|
| CAS Number | 1334106-34-1 | Molecular Weight | 443.624 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 582.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C29H37N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 306.1±28.7 °C | |
Use of ASS234ASS234 (ASS-234) is a multitarget, potent, and CNS permeable inhibitor with IC50 of 5.2, 43, 350 and 460 nM for MAO-1, MAO-B, EeAChE and eqBuChE, respectively; inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro; completely blocks the aggregation mediated by AChE of both Aβ1-42 and Aβ1-40, showing a dual binding site to AChE; ASS234 significantly reduces Aβ1-42-mediated toxicity in SH-SY5Y human neuroblastoma cells, ASS234 is a promising multitarget drug candidates with potential impact for Alzheimer's disease. |
| Name | ASS234 |
|---|---|
| Synonym | More Synonyms |
| Description | ASS234 (ASS-234) is a multitarget, potent, and CNS permeable inhibitor with IC50 of 5.2, 43, 350 and 460 nM for MAO-1, MAO-B, EeAChE and eqBuChE, respectively; inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro; completely blocks the aggregation mediated by AChE of both Aβ1-42 and Aβ1-40, showing a dual binding site to AChE; ASS234 significantly reduces Aβ1-42-mediated toxicity in SH-SY5Y human neuroblastoma cells, ASS234 is a promising multitarget drug candidates with potential impact for Alzheimer's disease. |
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| References | References 1. Bolea I, et al. J Med Chem. 2011 Dec 22;54(24):8251-70. 2. Bolea I, et al. Curr Alzheimer Res. 2013 Oct;10(8):797-808. 3. del Pino J, et al. CNS Neurosci Ther. 2014 Jun;20(6):568-70. 4. Marco-Contelles J, et al. Front Neurosci. 2016 Jun 28;10:294. View Related Products by Target Monoamine Oxidase (MAO) |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 582.5±45.0 °C at 760 mmHg |
| Molecular Formula | C29H37N3O |
| Molecular Weight | 443.624 |
| Flash Point | 306.1±28.7 °C |
| Exact Mass | 443.293671 |
| LogP | 5.74 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.573 |
| ASS234 |
| N-({5-[3-(1-Benzyl-4-piperidinyl)propoxy]-1-methyl-1H-indol-2-yl}methyl)-N-methyl-2-propyn-1-amine |
| 1H-Indole-2-methanamine, N,1-dimethyl-5-[3-[1-(phenylmethyl)-4-piperidinyl]propoxy]-N-2-propyn-1-yl- |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: ASS234
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: ASS234
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: ASS234
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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