Zidovudine O-β-D-glucuronide sodium

Modify Date: 2024-01-17 22:34:30

Zidovudine O-β-D-glucuronide sodium structure	Common Name	Zidovudine O-β-D-glucuronide sodium
	CAS Number	133525-01-6	Molecular Weight	465.34700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₀N₅NaO₁₀	Melting Point	158-163ºC
	MSDS	N/A	Flash Point	N/A

Use of Zidovudine O-β-D-glucuronide sodium

Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection[1][2].

Name	3'-AZIDO-3'-DEOXYTHYMIDINE β-D-GLUCURONIDE, SODIUM SALT

Description	Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection[1][2].
Related Catalog	Research Areas >> Others
References	[1]. Fayz S, et, al. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother. 1998 Jul;42(7):1654-8. [2]. Bélanger AS, et, al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos. 2009 Sep;37(9):1793-6.

Description

Related Catalog

Research Areas >> Others

References

[1]. Fayz S, et, al. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother. 1998 Jul;42(7):1654-8.

[2]. Bélanger AS, et, al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos. 2009 Sep;37(9):1793-6.

Melting Point	158-163ºC
Molecular Formula	C₁₆H₂₀N₅NaO₁₀
Molecular Weight	465.34700
Exact Mass	465.11100
PSA	208.09000
Storage condition	-20°C Freezer, Under Inert Atmosphere

Zidovudine O-β-D-glucuronide sodium

Use of Zidovudine O-β-D-glucuronide sodium

Names

Zidovudine O-β-D-glucuronide sodium Biological Activity

Chemical & Physical Properties