ONO4057
Modify Date: 2024-01-12 14:13:32
ONO4057 structure
|
Common Name | ONO4057 | ||
|---|---|---|---|---|
| CAS Number | 134578-96-4 | Molecular Weight | 470.55500 | |
| Density | 1.173g/cm3 | Boiling Point | 704.8ºC at 760mmHg | |
| Molecular Formula | C27H34O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 233.1ºC | |
Use of ONO4057ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM. |
| Name | 5-[2-(2-carboxyethyl)-3-[(E)-6-(4-methoxyphenyl)hex-5-enoxy]phenoxy]pentanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM. |
|---|---|
| Related Catalog | |
| Target |
LTB4:0.7 μM (IC50) |
| In Vivo | Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2]. |
| Animal Admin | Inbred male ACI (180 to 210 g) and LEW (200 to 240 g) rats are used as donors and recipients. Liver transplantation is orthotopically performed. ONO4057 dissolved in 7% NaHCO3 or solvent is administered subcutaneously daily after transplantation. Animals are divided into two groups: group I (n=5), 7% NaHCO3 3 mL/kg as controls; group II (n=6), ONO4057 30 mg/kg per day[2]. |
| References |
| Density | 1.173g/cm3 |
|---|---|
| Boiling Point | 704.8ºC at 760mmHg |
| Molecular Formula | C27H34O7 |
| Molecular Weight | 470.55500 |
| Flash Point | 233.1ºC |
| Exact Mass | 470.23000 |
| PSA | 102.29000 |
| LogP | 5.60860 |
| Vapour Pressure | 7.52E-21mmHg at 25°C |
| Index of Refraction | 1.569 |
| Storage condition | 2-8℃ |
| Benzenepropanoic acid,2-(4-carboxybutoxy)-6-((6-(4-methoxyphenyl)-5-hexenyl)oxy)-,(E) |
| Ono 4057 |
| 5-(2-(2-Carboxyethyl)-3-(6-(4-methoxyphenyl)-5E-hexenyl)oxyphenoxy)valeric acid |
| Ono-LB-457 |
| ONO4057 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: ONO4057
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: ONO-LB 457
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: $1920/1mg
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