Sibiriline
Modify Date: 2024-01-09 12:44:24
Sibiriline structure
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Common Name | Sibiriline | ||
|---|---|---|---|---|
| CAS Number | 1346526-26-8 | Molecular Weight | 210.231 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 457.4±30.0 °C at 760 mmHg | |
| Molecular Formula | C13H10N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 230.4±24.6 °C | |
Use of SibirilineA specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis. |
| Name | 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol |
|---|---|
| Synonym | More Synonyms |
| Description | A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis. |
|---|---|
| References | References 1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176. View Related Products by Target RIP kinase |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 457.4±30.0 °C at 760 mmHg |
| Molecular Formula | C13H10N2O |
| Molecular Weight | 210.231 |
| Flash Point | 230.4±24.6 °C |
| Exact Mass | 210.079315 |
| LogP | 3.59 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.726 |
| Phenol, 4-(1H-pyrrolo[2,3-b]pyridin-2-yl)- |
| 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Sibiriline
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tom
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: Sibiriline
- Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/250mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Sibiriline
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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