di-Pal-MTO

Modify Date: 2024-04-06 22:25:49

di-Pal-MTO Structure
di-Pal-MTO structure
Common Name di-Pal-MTO
CAS Number 1349197-90-5 Molecular Weight 917.27
Density N/A Boiling Point N/A
Molecular Formula C54H84N4O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of di-Pal-MTO


di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer drug mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity[1].

 Names

Name di-Pal-MTO

 di-Pal-MTO Biological Activity

Description di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer drug mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity[1].
Related Catalog
In Vitro Delivery of Mcl-1-specific anticancer siRNA (siMcl-1) using nanoparticles of mono-Pal-MTO and di-Pal-MTO (md11-Pal-MTO) in a 1:1 molar ratio enhances in vitro antitumour activity, reducing tumour cell viability by 81% and tumour size by 83%. Lipofectamine 2000-mediated transfection with siMcl-1 reduces tumour cell viability by 68%[1].
References

[1]. Rae Sung Chang, et al. Cationic drug-derived nanoparticles for multifunctional delivery of anticancer siRNA. Biomaterials. 2011 Dec;32(36):9785-95.  

 Chemical & Physical Properties

Molecular Formula C54H84N4O8
Molecular Weight 917.27
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