Bimagrumab structure
|
Common Name | Bimagrumab | ||
---|---|---|---|---|
CAS Number | 1356922-05-8 | Molecular Weight | N/A | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | N/A | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of BimagrumabBimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness[1][2]. |
Name | Bimagrumab |
---|
Description | Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness[1][2]. |
---|---|
Related Catalog | |
Target |
ACVR2B:1.7 pM (Kd) ACVR2A:434 pM (Kd) |
In Vitro | BYM338 (1 pM-1 μM; 24 h) 抑制 HEK293 细胞中 Myostatin 和 Activin A- 诱导的 Smad2/3 依赖性荧光素酶反应,IC50 值分别为 154 和 343[2]。 BYM338 (4 days) 可防止外源添加 Myostatin 或 Activin A 诱导的分化和融合抑制[2]。 |
In Vivo | BYM338 (6-20 mg/kg; 皮下注射,每周一次,持续 4 周) 促进所有检查肌肉的体重增加和骨骼肌肥大,包括慢速、快速和混合肌肉[2]。 BYM338 (5-20 mg/kg;皮下注射,每周一次,持续 14 天) 可防止糖皮质激素诱导的小鼠肌肉萎缩[2]。 |
References |
No Any Chemical & Physical Properties |