![]() RO-5353 structure
|
Common Name | RO-5353 | ||
---|---|---|---|---|
CAS Number | 1360821-61-9 | Molecular Weight | 619.534 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 759.1±60.0 °C at 760 mmHg | |
Molecular Formula | C29H29Cl2FN4O4S | Melting Point | N/A | |
MSDS | N/A | Flash Point | 412.9±32.9 °C |
Use of RO-5353A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg. |
Name | (2S,3R,4R,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide |
---|---|
Synonym | More Synonyms |
Description | A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg. |
---|---|
References | References 1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. View Related Products by Target MDM2-p53 |
Density | 1.5±0.1 g/cm3 |
---|---|
Boiling Point | 759.1±60.0 °C at 760 mmHg |
Molecular Formula | C29H29Cl2FN4O4S |
Molecular Weight | 619.534 |
Flash Point | 412.9±32.9 °C |
Exact Mass | 618.127075 |
LogP | 6.32 |
Vapour Pressure | 0.0±2.6 mmHg at 25°C |
Index of Refraction | 1.663 |
Spiro[pyrrolidine-3,6'-[6H]thieno[3,2-b]pyrrole]-5-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-4',5'-dihydro-5'-oxo-, (2S,3R,4R,5R)- |
(2S,3R,4R,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide |