proTAME
Modify Date: 2024-04-05 15:18:17
proTAME structure
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Common Name | proTAME | ||
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| CAS Number | 1362911-19-0 | Molecular Weight | 726.750 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C34H38N4O12S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of proTAMEproTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20); arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC); efficiently targets osteosarcoma in vitro combined with chemotherapeutic agents. |
| Name | Methyl N2-[(4-methylphenyl)sulfonyl]-N5-(2,6,10,14-tetraoxo-1,15-diphenyl-3,5,11,13-tetraoxa-7,9-diazapentadecan-8-ylidene)-L-ornithinate |
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| Synonym | More Synonyms |
| Description | proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20); arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC); efficiently targets osteosarcoma in vitro combined with chemotherapeutic agents. |
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| References | References 1. Zeng X, et al. Cancer Cell. 2010 Oct 19;18(4):382-95. 2. Giovinazzi S, et al. Cell Cycle. 2013 Aug 15;12(16):2598-607. 3. Hu K, et al. Oncotarget. 2014 May 30;5(10):3088-100. View Related Products by Target E3 Ubiquitin Ligase |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C34H38N4O12S |
| Molecular Weight | 726.750 |
| Exact Mass | 726.220703 |
| LogP | 6.05 |
| Index of Refraction | 1.587 |
| L-Ornithine, N5-[bis[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]methylene]-N2-[(4-methylphenyl)sulfonyl]-, methyl ester |
| Methyl N2-[(4-methylphenyl)sulfonyl]-N5-(2,6,10,14-tetraoxo-1,15-diphenyl-3,5,11,13-tetraoxa-7,9-diazapentadecan-8-ylidene)-L-ornithinate |