JWH-424

Modify Date: 2024-01-14 21:18:59

JWH-424 structure	Common Name	JWH-424
	CAS Number	1366068-04-3	Molecular Weight	420.342
	Density	1.3±0.1 g/cm3	Boiling Point	572.4±25.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₂BrNO	Melting Point	N/A
	MSDS	N/A	Flash Point	300.0±23.2 °C

Use of JWH-424

JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively).

Name	(8-bromonaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	572.4±25.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₂BrNO
Molecular Weight	420.342
Flash Point	300.0±23.2 °C
Exact Mass	419.088470
PSA	22.00000
LogP	7.63
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.628

1-pentyl-1H-indole

CAS#:59529-21-4

8-bromo-1-napht...

CAS#:56268-44-1

~79%

JWH-424

CAS#:1366068-04-3

Literature: Wiley, Jenny L.; Smith, Valerie J.; Chen, Jianhong; Martin, Billy R.; Huffman, John W. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2067 - 2081

8-Bromo-1-napht...

CAS#:1729-99-3

JWH-424

CAS#:1366068-04-3

Literature: Wiley, Jenny L.; Smith, Valerie J.; Chen, Jianhong; Martin, Billy R.; Huffman, John W. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2067 - 2081

anhydro-2-p-Tol...

CAS#:6314-27-8

JWH-424

CAS#:1366068-04-3

Literature: Wiley, Jenny L.; Smith, Valerie J.; Chen, Jianhong; Martin, Billy R.; Huffman, John W. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2067 - 2081

Precursor 4
CAS#:59529-21-4 1-pentyl-1H-indole CAS#:56268-44-1 8-bromo-1-napht... CAS#:1729-99-3 8-Bromo-1-napht... CAS#:6314-27-8 anhydro-2-p-Tol...
DownStream 0