Calcium channel-modulator-1

Modify Date: 2024-01-07 19:34:25

Calcium channel-modulator-1 Structure
Calcium channel-modulator-1 structure
Common Name Calcium channel-modulator-1
CAS Number 136941-70-3 Molecular Weight 579.45
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Calcium channel-modulator-1


Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC50 of 0.8 μM.

 Names

Name Calcium channel-modulator-1

 Calcium channel-modulator-1 Biological Activity

Description Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC50 of 0.8 μM.
Related Catalog
Target

IC50: 0.8 μM (Aortic contraction)[1]

In Vivo Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine[1].
References

[1]. Sunkel CE, et al. Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators. J Med Chem. 1992 Jun 26;35(13):2407-14.

 Chemical & Physical Properties

Molecular Weight 579.45
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