Zifaxaban
Modify Date: 2024-05-11 18:22:46
Zifaxaban structure
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Common Name | Zifaxaban | ||
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| CAS Number | 1378266-98-8 | Molecular Weight | 429.877 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 680.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H16ClN3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 365.2±31.5 °C | |
Use of ZifaxabanZifaxaban is a novel, potent, selective, direct and oral factor Xa inhibitor with IC50 of 11.1 nM (human FXa), displays > 10,000-fold selectivity than other serine proteases; also deoes not impair platelet aggregation induced by collagen, adenosine diphosphate (ADP) or arachidonic acid; significantly prolongs clotting time, prothrombin time (PT), and activated partial thromboplastin time (APTT) in the plasma of humans, rabbits, and rats, with a relatively weak effect on thrombin time; strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg in venous thrombosis models in rats. |
| Name | 5-Chloro-N-({(5S)-2-oxo-3-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide |
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| Synonym | More Synonyms |
| Description | Zifaxaban is a novel, potent, selective, direct and oral factor Xa inhibitor with IC50 of 11.1 nM (human FXa), displays > 10,000-fold selectivity than other serine proteases; also deoes not impair platelet aggregation induced by collagen, adenosine diphosphate (ADP) or arachidonic acid; significantly prolongs clotting time, prothrombin time (PT), and activated partial thromboplastin time (APTT) in the plasma of humans, rabbits, and rats, with a relatively weak effect on thrombin time; strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg in venous thrombosis models in rats. |
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| References | References 1. Qiu X, et al. Eur J Pharmacol. 2018 Aug 17. pii: S0014-2999(18)30469-2. View Related Products by Target Factor Xa |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 680.2±55.0 °C at 760 mmHg |
| Molecular Formula | C20H16ClN3O4S |
| Molecular Weight | 429.877 |
| Flash Point | 365.2±31.5 °C |
| Exact Mass | 429.054993 |
| LogP | 2.45 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.663 |
| 5-Chloro-N-({(5S)-2-oxo-3-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide |
| 2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-5-oxazolidinyl]methyl]- |