CBB1007
Modify Date: 2024-01-12 10:48:32
CBB1007 structure
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Common Name | CBB1007 | ||
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| CAS Number | 1379573-92-8 | Molecular Weight | 534.610 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 763.8±70.0 °C at 760 mmHg | |
| Molecular Formula | C27H34N8O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 415.7±35.7 °C | |
Use of CBB1007CBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1).IC50 Value: 5.27 uMTarget: hLSD1CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ≤ 5 μM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM). CBB1007 was Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 ≥ 100 μM). |
| Name | Methyl 3-{[4-(4-carbamimidoylbenzoyl)-1-piperazinyl]carbonyl}-5-[(4-carbamimidoyl-1-piperazinyl)methyl]benzoate |
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| Synonym | More Synonyms |
| Description | CBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1).IC50 Value: 5.27 uMTarget: hLSD1CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ≤ 5 μM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM). CBB1007 was Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 ≥ 100 μM). |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 763.8±70.0 °C at 760 mmHg |
| Molecular Formula | C27H34N8O4 |
| Molecular Weight | 534.610 |
| Flash Point | 415.7±35.7 °C |
| Exact Mass | 534.270325 |
| PSA | 173.14000 |
| LogP | -2.99 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.682 |
| Storage condition | 2-8℃ |
| Methyl 3-{[4-(4-carbamimidoylbenzoyl)-1-piperazinyl]carbonyl}-5-[(4-carbamimidoyl-1-piperazinyl)methyl]benzoate |
| Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester |
| CBB1007 |