Strychnidin-10-one hydrochloride (1:1)

Modify Date: 2024-01-01 18:22:09

Strychnidin-10-one hydrochloride (1:1) Structure
Strychnidin-10-one hydrochloride (1:1) structure
Common Name Strychnidin-10-one hydrochloride (1:1)
CAS Number 1421-86-9 Molecular Weight 370.872
Density N/A Boiling Point 559.9ºC at 760mmHg
Molecular Formula C21H23ClN2O2 Melting Point 295 °C
MSDS Chinese USA Flash Point 292.4ºC
Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger

 Use of Strychnidin-10-one hydrochloride (1:1)


Strychnine Hydrochloride is a neurotoxin that acts as an antagonist of glycine and acetylcholine receptors.

 Names

Name Strychnine hydrochloride,Strychnidin-10-onehydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 559.9ºC at 760mmHg
Melting Point 295 °C
Molecular Formula C21H23ClN2O2
Molecular Weight 370.872
Flash Point 292.4ºC
Exact Mass 370.144806
PSA 32.78000
LogP 2.89740
Vapour Pressure 1.44E-12mmHg at 25°C
Storage condition Store at RT

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WL2430000
CHEMICAL NAME :
Strychnine, monohydrochloride
CAS REGISTRY NUMBER :
1421-86-9
LAST UPDATED :
199106
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C21-H22-N2-O2.Cl-H
MOLECULAR WEIGHT :
370.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2730 ug/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 ug/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
460 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :
Gene conversion and mitotic recombination
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
3 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10,27,1987

 Safety Information

Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger
Hazard Statements H300-H330-H410
Precautionary Statements P260-P264-P273-P284-P301 + P310-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T+: Very toxic;N: Dangerous for the environment;
Risk Phrases R26/27/28
Safety Phrases S22-S36/37/39-S45-S61-S60
RIDADR UN 1692 6.1/PG 1
WGK Germany 3
RTECS WL2430000
Packaging Group I
Hazard Class 6.1(a)

 Articles12

More Articles
Parallel ON and OFF cone bipolar inputs establish spatially coextensive receptive field structure of blue-yellow ganglion cells in primate retina.

J. Mol. Endocrinol. 29 , 8372-87, (2009)

In the primate retina the small bistratified, "blue-yellow" color-opponent ganglion cell receives parallel ON-depolarizing and OFF-hyperpolarizing inputs from short (S)-wavelength sensitive and combin...

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release.

J. Immunol. 195 , 2325-34, (2015)

IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host defense against infection. However, increased production of IL-1β plays a pathogenic role in various inf...

Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.

J. Neurosci. 35 , 7626-42, (2015)

The superficial dorsal horn of the spinal cord contains numerous inhibitory interneurons, which regulate the transmission of information perceived as touch, pain, or itch. Despite the importance of th...

 Synonyms

strychnine*HCl
Strychnin,Hydrochlorid
MFCD00058174
strychnine,monohydrochloride
Strychnidin-10-onehydrochloride
EINECS 215-826-9
Strychnidin-10-one, hydrochloride (1:1)
strychnine,hydrochloride
Strychnidin-10-one hydrochloride (1:1)
Strychnidin-10-one, monohydrochloride (9CI)
strychnidin-10-one,monohydrochloride
Strychnine Hydrochloride Hydrate
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