ANAKINRA
Modify Date: 2024-01-02 11:50:17
ANAKINRA structure
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Common Name | ANAKINRA | ||
|---|---|---|---|---|
| CAS Number | 143090-92-0 | Molecular Weight | 509.556 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C759H1186N208O232S10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ANAKINRAAnakinra is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Anakinra is the first biological agent to block the pro-inflammatory effects[1][2]. |
| Name | ANAKINRA |
|---|---|
| Synonym | More Synonyms |
| Description | Anakinra is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Anakinra is the first biological agent to block the pro-inflammatory effects[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IL-1R[1]. |
| In Vivo | Combined etanercept (5 mg/kg, ip) and Anakinra (100 mg/kg, I.P. daily for 7 days) substantially improves marginal mass human islet engraftment in immunodeficient mice[2]. Anakinra enhances tumor growth inhibition in mice receiving peptide vaccination and β-(1-3),(1-6)-D-glucan[3]. |
| References |
[1]. Cvetkovic RS, et al. Anakinra. BioDrugs. 2002;16(4):303-11; discussion 313-4. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C759H1186N208O232S10 |
| Molecular Weight | 509.556 |
| Exact Mass | 509.103882 |
| LogP | 2.69 |
| Index of Refraction | 1.705 |
| (7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-({[(2,2-dimethylpropanoyl)oxy]methoxy}imino)acetyl]amino}-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[[(2,2-dimethyl-1-oxopropoxy)methoxy]imino]-1-oxoethyl]amino]-3-ethenyl-8-oxo-, (7R)- |