Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt

Modify Date: 2024-01-03 19:49:57

Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt structure	Common Name	Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt
	CAS Number	143113-45-5	Molecular Weight	2006.32
	Density	1.3±0.1 g/cm3	Boiling Point	2125.8±65.0 °C at 760 mmHg
	Molecular Formula	C₉₆H₁₄₀N₂₀O₂₅S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	1239.5±34.3 °C

Use of Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt

BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.

Name	bq-3020
Synonym	More Synonyms

Description	BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	ETB:0.2 nM (IC50)
References	[1]. Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94. [2]. Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52. [3]. Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262.

Density	1.3±0.1 g/cm3
Boiling Point	2125.8±65.0 °C at 760 mmHg
Molecular Formula	C₉₆H₁₄₀N₂₀O₂₅S
Molecular Weight	2006.32
Flash Point	1239.5±34.3 °C
Exact Mass	2005.001953
PSA	730.82000
LogP	6.02
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.582

RIDADR	NONH for all modes of transport

Endothelin-1 stimulates aldosterone synthesis in Conn's adenomas via both A and B receptors coupled with the protein kinase C- and cyclooxygenase-dependent signaling pathways.

J. Investig. Med. 48(5) , 343-50, (2000)

The mechanisms and factors leading to enhanced aldosterone secretion and ultimately to neoplastic transformation of the adrenal cortex are poorly defined. Angiotensin-II (Ang-II) and endothelin-1 (ET-...

Marked reduction of mortality in salt-loaded Dahl salt-sensitive rats by the new, selective endothelin ETA receptor antagonist, J-105859.

J. Hypertens. 18(12) , 1815-23, (2000)

To examine the chronic effects of a newly synthesized, potent and selective endothelin (ET) ETA receptor antagonist, J-1 05859, on mortality in salt-loaded Dahl salt-sensitive (DS) rats and to confirm...

Mechanisms involved in the effects of endothelin-1 in pig prostatic small arteries.

Eur. J. Pharmacol. 640(1-3) , 190-6, (2010)

Since endothelin-1 (ET-1) is involved in prostatic disorders, the current study investigated the mechanisms underlying the ET-1-induced effects in pig prostatic small arteries. The experiments were pe...

N-Acetyl-[Ala11,15]-Endothelin 1 fragment 6-21

MFCD00214633

Acetyl-(Ala 11,15)-ET 1 (6-21)

N-Acetyl-L-leucyl-L-methionyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan

L-Tryptophan, N-acetyl-L-leucyl-L-methionyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-

Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt

Use of Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt

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