TASP 0433864
Modify Date: 2024-01-02 15:44:11
TASP 0433864 structure
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Common Name | TASP 0433864 | ||
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| CAS Number | 1431980-60-7 | Molecular Weight | 329.393 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 521.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H23N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 269.1±32.9 °C | |
Use of TASP 0433864A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity; has negligible activities for other mGlu receptors, including mGlu3 receptor; potentiates the mGlu2 receptor-mediated presynaptic inhibition of glutamate release, inhibits both MK-801- and ketamine-increased cortical γ band oscillation in the rat cortical electroencephalogram; significantly inhibits both ketamine- and methamphetamine-increased locomotor activities in mice. |
| Name | (2S)-5-Methyl-2-{[4-(2-methyl-2-propanyl)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole-6-carboxamide |
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| Synonym | More Synonyms |
| Description | A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity; has negligible activities for other mGlu receptors, including mGlu3 receptor; potentiates the mGlu2 receptor-mediated presynaptic inhibition of glutamate release, inhibits both MK-801- and ketamine-increased cortical γ band oscillation in the rat cortical electroencephalogram; significantly inhibits both ketamine- and methamphetamine-increased locomotor activities in mice. |
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| References | References 1. Hiyoshi T, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):642-53. View Related Products by Target mGluR |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 521.4±60.0 °C at 760 mmHg |
| Molecular Formula | C18H23N3O3 |
| Molecular Weight | 329.393 |
| Flash Point | 269.1±32.9 °C |
| Exact Mass | 329.173950 |
| LogP | 2.45 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.607 |
| MFCD30720884 |
| (2S)-5-Methyl-2-{[4-(2-methyl-2-propanyl)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole-6-carboxamide |
| Imidazo[2,1-b]oxazole-6-carboxamide, 2-[[4-(1,1-dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methyl-, (2S)- |