PK-7088
Modify Date: 2024-05-01 20:04:29
PK-7088 structure
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Common Name | PK-7088 | ||
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| CAS Number | 1446352-67-5 | Molecular Weight | 223.279 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H13N3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PK-7088PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria. |
| Name | PK-7088 |
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| Description | PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria. |
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| References | References 1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44. 2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. 3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7. View Related Products by Target MDM2-p53 |
| Molecular Formula | C14H13N3 |
|---|---|
| Molecular Weight | 223.279 |