4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester

Modify Date: 2024-01-21 18:36:26

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure
4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester structure
Common Name 4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester
CAS Number 144702-26-1 Molecular Weight 570.72300
Density 1.16 Boiling Point 780.446ºC at 760 mmHg
Molecular Formula C37H38N4O2 Melting Point N/A
MSDS N/A Flash Point 425.798ºC

 Names

Name Telmisartan tert-Butyl Ester
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.16
Boiling Point 780.446ºC at 760 mmHg
Molecular Formula C37H38N4O2
Molecular Weight 570.72300
Flash Point 425.798ºC
Exact Mass 570.29900
PSA 61.94000
LogP 8.52150

 Synthetic Route

~62%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: ZAKLADY FARMACEUTYCZNE POLPHARMA SA Patent: WO2009/123483 A1, 2009 ; Location in patent: Page/Page column 18-19 ;

~72%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: Kumar, A. Sanjeev; Ghosh, Samir; Mehta Journal of Chemical Research, 2010 , # 2 p. 95 - 97

~%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051

~%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051

~%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051

~%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051

~%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051

~%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051

~%

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester Structure

4'-[[1,4'-Dimet...

CAS#:144702-26-1

Literature: Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051

 Synonyms

tert-butyl 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoate
4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester
Telmisartan Impurity 3