(1S,2S)-trans-N-Boc-2-aminocyclopentanol

Modify Date: 2024-01-09 18:52:02

(1S,2S)-trans-N-Boc-2-aminocyclopentanol Structure
(1S,2S)-trans-N-Boc-2-aminocyclopentanol structure
Common Name (1S,2S)-trans-N-Boc-2-aminocyclopentanol
CAS Number 145106-43-0 Molecular Weight 201.26300
Density 1.08±0.1 g/cm3 (20 ºC 760 Torr) Boiling Point N/A
Molecular Formula C10H19NO3 Melting Point 87.0℃
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Names

Name tert-butyl N-[(1S,2S)-2-hydroxycyclopentyl]carbamate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.08±0.1 g/cm3 (20 ºC 760 Torr)
Melting Point 87.0℃
Molecular Formula C10H19NO3
Molecular Weight 201.26300
Exact Mass 201.13600
PSA 62.05000
LogP 1.62890
Storage condition 2-8°C

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H400
Precautionary Statements P273
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;N: Dangerous for the environment;
Risk Phrases R22
Safety Phrases S61
RIDADR UN 3077 9/PG 3

 Synthetic Route

~99%

(1S,2S)-trans-N-Boc-2-aminocyclopentanol Structure

(1S,2S)-trans-N...

CAS#:145106-43-0

Literature: BRISTOL-MYERS SQUIBB COMPANY Patent: WO2003/99276 A1, 2003 ; Location in patent: Page 267 ; WO 03/099276 A1

~88%

(1S,2S)-trans-N-Boc-2-aminocyclopentanol Structure

(1S,2S)-trans-N...

CAS#:145106-43-0

Literature: ELI LILLY AND COMPANY; JADHAV, Prabhakar Kondaji; SAEED, Ashraf; GREEN, Jonathan Edward; KRISHNAN, Venkatesh; MATTHEWS, Donald Paul; STEPHENSON, Gregory Alan Patent: WO2013/55577 A1, 2013 ; Location in patent: Page/Page column 33 ;

~71%

(1S,2S)-trans-N-Boc-2-aminocyclopentanol Structure

(1S,2S)-trans-N...

CAS#:145106-43-0

Literature: Jin, Yonghao; Roycik, Mark D.; Bosco, Dale B.; Cao, Qiang; Constantino, Manuel H.; Schwartz, Martin A.; Sang, Qing-Xiang Amy Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4357 - 4373

~96%

(1S,2S)-trans-N-Boc-2-aminocyclopentanol Structure

(1S,2S)-trans-N...

CAS#:145106-43-0

Literature: Aube; Wolfe; Yantiss; Cook; Takusagawa Synthetic Communications, 1992 , vol. 22, # 20 p. 3003 - 3012

~%

(1S,2S)-trans-N-Boc-2-aminocyclopentanol Structure

(1S,2S)-trans-N...

CAS#:145106-43-0

Literature: Qiao, Jennifer X.; Chang, Chong-Hwan; Cheney, Daniel L.; Morin, Paul E.; Wang, Gren Z.; King, Sarah R.; Wang, Tammy C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R.; Lam, Patrick Y.S. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4419 - 4427

~%

(1S,2S)-trans-N-Boc-2-aminocyclopentanol Structure

(1S,2S)-trans-N...

CAS#:145106-43-0

Literature: Govindaraju; Kumar, Vaijayanti A; Ganesh, Krishna N Chemical communications (Cambridge, England), 2004 , # 7 p. 860 - 861

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

tert-Butyl,(1S,2S)-2-hydroxycyclopentyl)carbamate
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