VU 0467485
Modify Date: 2024-02-01 11:41:06
VU 0467485 structure
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Common Name | VU 0467485 | ||
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| CAS Number | 1451994-10-7 | Molecular Weight | 360.406 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C17H17FN4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU 0467485VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4); possesses robust in vitro M4 PAM potency across species and in vivo efficacy in preclinical models of schizophrenia. |
| Name | 5-Amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide |
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| Synonym | More Synonyms |
| Description | VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4); possesses robust in vitro M4 PAM potency across species and in vivo efficacy in preclinical models of schizophrenia. |
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| References | References 1. Wood MR, et al. ACS Med Chem Lett. 2016 Dec 16;8(2):233-238. 2. Melancon BJ, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2296-2301. 3. Deng X, et al. ChemMedChem. 2018 Dec 27. doi: 10.1002/cmdc.201800710. View Related Products by Target mAChR |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C17H17FN4O2S |
| Molecular Weight | 360.406 |
| Exact Mass | 360.105621 |
| LogP | 3.11 |
| Index of Refraction | 1.660 |
| 5-Amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide |
| Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethyl- |