Heterophyllin B

Modify Date: 2024-01-02 18:00:54

Heterophyllin B Structure
Heterophyllin B structure
 Common Name Heterophyllin B
CAS Number 145459-19-4 Molecular Weight 778.937
Density 1.3±0.1 g/cm3 Boiling Point 1159.7±65.0 °C at 760 mmHg
Molecular Formula C40H58N8O8 Melting Point N/A
MSDS N/A Flash Point 655.1±34.3 °C

 Use of Heterophyllin B


Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer[1].

 Names

Name Cyclo(glycylglycyl-L-isoleucyl-L-prolyl-L-prolyl-L-prolyl-L-isole ucyl-L-phenylalanyl)
Synonym More Synonyms

 Heterophyllin B Biological Activity

Description Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer[1].
Related Catalog
In Vitro Heterophyllin B (0-200 µM; 12-48 hours) reduces cell viability in the 75, 100 and 200 µM groups, has no effect on 5, 10, 25 and 50 µM groups[1]. Heterophyllin B (0-50 µM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells[1]. Cell Viability Assay[1] Cell Line: ECA-109 cells Concentration: 5 µM, 10 µM, 25 µM, 50 µM, 75 µM, 100 µM and 200 µM Incubation Time: 12, 24 and 48 hours Result: Decreased cell viability at high concentrations. Western Blot Analysis[1] Cell Line: ECA-109 cells Concentration: 0 µM, 10 µM, 25 µM, 50 µM Incubation Time: 6 hours Result: Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin.
References

[1]. Tantai JC, et al. Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K/AKT/β-catenin signaling. Mol Med Rep. 2016 Feb;13(2):1097-104.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1159.7±65.0 °C at 760 mmHg
Molecular Formula C40H58N8O8
Molecular Weight 778.937
Flash Point 655.1±34.3 °C
Exact Mass 778.437744
PSA 223.88000
LogP -1.82
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.604

 Synonyms

Cyclo(glycylglycyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-phenylalanyl)
Heterophyllin B
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