CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TP2505900
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CHEMICAL NAME :
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Platinum, (2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N, N')(propanedioato(2-) -O,O')-, (SP-4-2-(4R-(2-alpha,4-alpha,5-beta)))-
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CAS REGISTRY NUMBER :
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146665-77-2
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LAST UPDATED :
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199509
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C11-H20-N2-O6-Pt
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MOLECULAR WEIGHT :
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471.42
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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182 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1590 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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198 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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235 mg/kg/13W-I
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TOXIC EFFECTS :
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Blood - normocytic anemia Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,217,1992
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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15 mg/kg/90D-I
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death
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REFERENCE :
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KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,235,1992
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