SRS11-92
Modify Date: 2024-01-12 11:39:31
SRS11-92 structure
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Common Name | SRS11-92 | ||
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| CAS Number | 1467047-25-1 | Molecular Weight | 352.470 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 523.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C22H28N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 270.5±28.7 °C | |
Use of SRS11-92SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM; inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2 uM, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM; also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease in a concentration-dependent manner. |
| Name | Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate |
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| Synonym | More Synonyms |
| Description | SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM; inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2 uM, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM; also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease in a concentration-dependent manner. |
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| References | References 1. Cotticelli MG, et al. J Pharmacol Exp Ther. 2019 Jan 11. pii: jpet.118.252759. 2. Linkermann A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. View Related Products by Target Ferroptosis |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 523.7±45.0 °C at 760 mmHg |
| Molecular Formula | C22H28N2O2 |
| Molecular Weight | 352.470 |
| Flash Point | 270.5±28.7 °C |
| Exact Mass | 352.215088 |
| LogP | 6.37 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.619 |
| Benzoic acid, 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-, ethyl ester |
| Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate |