HIV-1 Integrase inhibitor GS-B
Modify Date: 2024-01-18 21:32:10
HIV-1 Integrase inhibitor GS-B structure
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Common Name | HIV-1 Integrase inhibitor GS-B | ||
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| CAS Number | 1470372-00-9 | Molecular Weight | 437.511 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H28FNO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIV-1 Integrase inhibitor GS-BHIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.GS-B displays antiviral potency in MT-4, MT-2, and human PBMCs with EC50 values of 18, 10, and 21 nM, respectively. |
| Name | HIV-1 Integrase inhibitor GS-B |
|---|
| Description | HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.GS-B displays antiviral potency in MT-4, MT-2, and human PBMCs with EC50 values of 18, 10, and 21 nM, respectively. |
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| References | 1. Manuel Tsiang, et al. J Biol Chem. 2012 Jun 15;287(25):21189-203. 2. Mini Balakrishnan, et al. PLoS One. 2013 Sep 9;8(9):e74163. 3. Yoshitsugu Ohata, et al. J Virol. 2022 Jan 19;JVI0184321. |
| Molecular Formula | C26H28FNO4 |
|---|---|
| Molecular Weight | 437.511 |