N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide

N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide structure	Common Name	N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
CAS Number	147118-37-4	Molecular Weight	351.396
Density	1.3±0.1 g/cm3	Boiling Point	536.6±60.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₈FN₃O₃S	Melting Point	180 °C
MSDS	N/A	Flash Point	278.3±32.9 °C

Name	N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	536.6±60.0 °C at 760 mmHg
Melting Point	180 °C
Molecular Formula	C₁₆H₁₈FN₃O₃S
Molecular Weight	351.396
Flash Point	278.3±32.9 °C
Exact Mass	351.105286
PSA	88.61000
LogP	1.03
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.575
Storage condition	Refrigerator

4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N- Revision number: 5
methanesulfonylamino)-5-pyrimidinecarboxaldehyde
SAFETY DATA SHEET

Section1. IDENTIFICATION
Product name:4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)-5-
pyrimidinecarboxaldehyde

Revision number:5

Section2. HAZARDS IDENTIFICATION
GHS classification
Not classified
PHYSICAL HAZARDS
HEALTH HAZARDSNot classified
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements, including precautionary statements
Pictograms or hazard symbolsNone
Signal wordNo signal word
Hazard statementsNone
Precautionary statements:None

Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture:Substance
4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)-5-
Components:
pyrimidinecarboxaldehyde
>98.0%(LC)(N)
Percent:
CAS Number:147118-37-4
Chemical Formula:C16H18FN3O3S

Section4. FIRST AID MEASURES
Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Inhalation:
Get medical advice/attention if you feel unwell.
Remove/Take off immediately all contaminated clothing. Rinse skin with
Skin contact:
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Rinse cautiously with water for several minutes. Remove contact lenses, if present
Eye contact:
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion:Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders:A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

Section5. FIRE-FIGHTING MEASURES
Suitable extinguishingDry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
from the chemical:
4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-
methanesulfonylamino)-5-
pyrimidinecarboxaldehyde

Section5. FIRE-FIGHTING MEASURES
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

Section6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

Section7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions:Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Packaging material:Comply with laws.

Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Install a closed system or local exhaust as possible so that workers should not be
Engineering controls:
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Protective gloves.
Hand protection:
Eye protection:Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

Section9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C):Solid
Form:Crystal- Powder
White - Almost white
Colour:
Odour:No data available
pH: No data available
Melting point/freezing point:180°C
No data available
Boiling point/range:
Flash point:No data available
Flammability or explosive
limits:
No data available
Lower:
Upper:No data available
Relative density:No data available
Solubility(ies):
No data available
[Water]
[Other solvents]
Hot acetone
Soluble:
4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-
methanesulfonylamino)-5-
pyrimidinecarboxaldehyde

Section10. STABILITY AND REACTIVITY
Chemical stability:Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen fluoride, Sulfur
products:oxides

Section11. TOXICOLOGICAL INFORMATION
Acute Toxicity:No data available
Skin corrosion/irritation: No data available
Serious eyeNo data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC =No data available
No data available
NTP =
Reproductive toxicity:No data available

Section12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish:No data available
Crustacea:No data available
Algae:No data available
Persistence / degradability: No data available
BioaccumulativeNo data available
potential(BCF):
Mobility in soil
Log Pow:No data available
Soil adsorption (Koc):No data available
Henry's LawNo data available
constant(PaM3/mol):

Section13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.

Section14. TRANSPORT INFORMATION
Hazards Class:Does not correspond to the classification standard of the United Nations
UN-No:Not listed

Section15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-
methanesulfonylamino)-5-
pyrimidinecarboxaldehyde

SECTION 16 - ADDITIONAL INFORMATION
N/A

Hazard Codes	Xi
HS Code	2935009090

Precursor 7
CAS#:799842-07-2 N-[5-bromomethy... CAS#:147118-36-3 4-(4-fluorophen... CAS#:1092844-00-2 N-(5-cyano-4-(4... CAS#:124-63-0 Methanesulfonyl...
CAS#:114433-94-2 1-(4-fluorophen... CAS#:1207460-34-1 4-(4-fluorophen... CAS#:953776-62-0 N-[4-(4-fluorop...
DownStream 6
CAS#:289042-12-2 tert-Butyl 6-[(... CAS#:287714-41-4 Rosuvastatin CAS#:147118-40-9 Rosuvastatin me... CAS#:147118-39-6 5-Oxorosuvastat...
CAS#:147118-36-3 4-(4-fluorophen... CAS#:147118-38-5 7-[4-fluorophen...

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonylamino)pyrmidine-5-carboxaldehyde

N-[4-(4-fluorophenyl)-5-formyl-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)-5-pyrimidinecarboxaldehyde

Methanesulfonamide, N-[4-(4-fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-

N-[4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-Fluorophenyl)-5-formyl-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide

MFCD08458342

INTERMEDIATE OF ROSUVASTATIN

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

4-(4-FLUOROPHENYL)-6-ISOPROPYL-5-FORMYL-2 (N-METHYL-N-METHANESULFONYLAMINO) PYRIMIDINE

N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide

Names

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms