2-(Trifluoromethyl)pyridin-4-amine

Modify Date: 2024-01-09 13:06:59

2-(Trifluoromethyl)pyridin-4-amine Structure
2-(Trifluoromethyl)pyridin-4-amine structure
Common Name 2-(Trifluoromethyl)pyridin-4-amine
CAS Number 147149-98-2 Molecular Weight 162.113
Density 1.4±0.1 g/cm3 Boiling Point 230.7±40.0 °C at 760 mmHg
Molecular Formula C6H5F3N2 Melting Point 58-62°C
MSDS Chinese USA Flash Point 93.3±27.3 °C
Symbol GHS06
GHS06
Signal Word Danger

 Names

Name 4-Amino-2-(trifluoromethyl)pyridine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 230.7±40.0 °C at 760 mmHg
Melting Point 58-62°C
Molecular Formula C6H5F3N2
Molecular Weight 162.113
Flash Point 93.3±27.3 °C
Exact Mass 162.040482
PSA 38.91000
LogP 2.11
Vapour Pressure 0.1±0.5 mmHg at 25°C
Index of Refraction 1.479
Storage condition 2-8°C

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H319
Precautionary Statements P301 + P310-P305 + P351 + P338
Hazard Codes T,Xi
Risk Phrases 25-36-43
Safety Phrases 26-36/37
RIDADR 2811
Packaging Group
HS Code 2933399090

 Synthetic Route

~99%

2-(Trifluoromethyl)pyridin-4-amine Structure

2-(Trifluoromet...

CAS#:147149-98-2

Literature: Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163

~99%

2-(Trifluoromethyl)pyridin-4-amine Structure

2-(Trifluoromet...

CAS#:147149-98-2

Literature: Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163

~89%

2-(Trifluoromethyl)pyridin-4-amine Structure

2-(Trifluoromet...

CAS#:147149-98-2

Literature: Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746

~29%

2-(Trifluoromethyl)pyridin-4-amine Structure

2-(Trifluoromet...

CAS#:147149-98-2

Literature: Hedge, Vidyadhar B.; Renga, James M.; Owen, John M. Tetrahedron Letters, 2001 , vol. 42, # 10 p. 1847 - 1850

~%

2-(Trifluoromethyl)pyridin-4-amine Structure

2-(Trifluoromet...

CAS#:147149-98-2

Literature: Journal of Medicinal Chemistry, , vol. 36, # 6 p. 733 - 746

~%

2-(Trifluoromethyl)pyridin-4-amine Structure

2-(Trifluoromet...

CAS#:147149-98-2

Literature: Journal of Medicinal Chemistry, , vol. 36, # 6 p. 733 - 746

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-(Trifluoromethyl)pyridin-4-amine 4-Amino-2-trifluoromethylpyridine
2-(Trifluoromethyl)pyridin-4-amine
4-Amino-2-(trifluoromethyl)pyridine
4-Pyridinamine, 2-(trifluoromethyl)-
2-(Trifluoromethyl)-4-pyridinamine
2-trifluoromethyl-4-amino pyridine
4-Amino-2-trifluoromethylpyridine
Enasidenib Intermediate 4
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