Sacituzumab govitecan

Modify Date: 2024-01-17 17:59:54

Sacituzumab govitecan Structure
Sacituzumab govitecan structure
Common Name Sacituzumab govitecan
CAS Number 1491917-83-9 Molecular Weight 1601.77000
Density N/A Boiling Point N/A
Molecular Formula C76H104N12O24S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Sacituzumab govitecan


Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity[1].

 Names

Name Sacituzumab govitecan
Synonym More Synonyms

 Sacituzumab govitecan Biological Activity

Description Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity[1].
Related Catalog
In Vivo Sacituzumab govitecan (IMMU-132) (17.5 mg/kg; twice weekly for 4 weeks) results in significant anti-tumor effects in mice bearing human gastric cancer xenografts[1].
References

[1]. Cardillo TM, et al. Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers. Bioconjug Chem. 2015 May 20;26(5):919-31.

 Chemical & Physical Properties

Molecular Formula C76H104N12O24S
Molecular Weight 1601.77000
Exact Mass 1600.70000
PSA 499.15000
LogP 5.09770
Storage condition 2-8°C

 Synonyms

hRS7-SN38
IMMU-132
IMMU 132
N-[4-(-Carboxycyclohexylmethyl)]maleimide
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