GNE-3500
Modify Date: 2024-02-29 12:59:50
GNE-3500 structure
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Common Name | GNE-3500 | ||
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| CAS Number | 1537859-24-7 | Molecular Weight | 459.577 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 664.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H30FN3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 355.6±34.3 °C | |
Use of GNE-3500GNE-3500 (GNE3500) is a potent, selective, and orally bioavailable RORγ inhibitor with IC50 of 47 nM in IL-17 promoter assays; displays 75-fold selectivity over other ROR family members and >200-fold selectivity over 25 additional nuclear receptors; inhibits the production of all three IL-17 subtypes in murine CD4+ T cells with EC50 of 0.27-1.8 uM, also inhibits the production of IL-17AA and -AF by ILCs; shows in vitro ADME properties, in vivo PK, and dose-dependent inhibition of IL-17 in vivo. |
| Name | 1-[4-(3-Fluoro-4-{[(3S,6R)-3-methyl-1,1-dioxido-6-phenyl-1,2-thiazinan-2-yl]methyl}phenyl)-1-piperazinyl]ethanone |
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| Synonym | More Synonyms |
| Description | GNE-3500 (GNE3500) is a potent, selective, and orally bioavailable RORγ inhibitor with IC50 of 47 nM in IL-17 promoter assays; displays 75-fold selectivity over other ROR family members and >200-fold selectivity over 25 additional nuclear receptors; inhibits the production of all three IL-17 subtypes in murine CD4+ T cells with EC50 of 0.27-1.8 uM, also inhibits the production of IL-17AA and -AF by ILCs; shows in vitro ADME properties, in vivo PK, and dose-dependent inhibition of IL-17 in vivo. |
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| References | References 1. Fauber BP, et al. J Med Chem. 2015 Jul 9;58(13):5308-22. View Related Products by Target ROR |
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 664.4±65.0 °C at 760 mmHg |
| Molecular Formula | C24H30FN3O3S |
| Molecular Weight | 459.577 |
| Flash Point | 355.6±34.3 °C |
| Exact Mass | 459.199188 |
| LogP | 3.24 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.592 |
| 1-[4-(3-Fluoro-4-{[(3S,6R)-3-methyl-1,1-dioxido-6-phenyl-1,2-thiazinan-2-yl]methyl}phenyl)-1-piperazinyl]ethanone |
| Ethanone, 1-[4-[3-fluoro-4-[[(3S,6R)-tetrahydro-3-methyl-1,1-dioxido-6-phenyl-2H-1,2-thiazin-2-yl]methyl]phenyl]-1-piperazinyl]- |