Omuralide
Omuralide structure
|
Common Name | Omuralide | ||
|---|---|---|---|---|
| CAS Number | 154226-60-5 | Molecular Weight | 213.230 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 462.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C10H15NO4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 233.7±28.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of OmuralideA potent 20S proteasome inhibitor with IC50 of 49 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).. |
| Name | CLASTO-LACTACYSTIN β-LACTONE |
|---|---|
| Synonym | More Synonyms |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 462.9±45.0 °C at 760 mmHg |
| Molecular Formula | C10H15NO4 |
| Molecular Weight | 213.230 |
| Flash Point | 233.7±28.7 °C |
| Exact Mass | 213.100113 |
| PSA | 75.63000 |
| LogP | -1.40 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.534 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H315-H319-H335 |
| Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
| RIDADR | UN 2811 6.1 / PGIII |
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Proteasome inhibitor differentially regulates expression of the major immediate early genes of human cytomegalovirus in human central nervous system-derived cell lines.
Virus Res. 142(1-2) , 68-77, (2009) Proteasome inhibitor, which inhibits NF-kappaB activation, has been reported to activate c-Jun N-terminal kinase (JNK)-c-Jun pathway. In this study, we investigated the effects of proteasome inhibitor... |
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Turnover of StAR protein: roles for the proteasome and mitochondrial proteases.
Mol. Cell. Endocrinol. 265-266 , 51-8, (2007) Steroidogenic acute regulatory protein (StAR) is a mitochondrial protein essential for massive synthesis of steroid hormones in the adrenal and the gonads. Our studies suggest that once synthesized on... |
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Targeting of a chlamydial protease impedes intracellular bacterial growth.
PLoS Pathog. 7(9) , e1002283, (2011) Chlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. Recent work has shown that growth of Chlamydia induces the fragmentation of the Golgi apparatus (GA) into ministac... |
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