Simmiparib
Modify Date: 2024-02-04 11:32:50
Simmiparib structure
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Common Name | Simmiparib | ||
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| CAS Number | 1551355-46-4 | Molecular Weight | 486.431 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H18F4N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SimmiparibSimmiparib is a novel potent, orally active PARP1/2 inhibitor with IC50 of 1.75/0.22 nM, inhibits PARP1 >90-fold more potently than the other PARPs (PARP3, TNKS1, TNKS2); selectively induces the accumulation of DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination repair (HR)-deficient cells; potentiates the proliferative inhibition of several conventional anticancer drugs, reduces the poly(ADP-ribose) formation in HR-deficient cancer cells and xenografts; exhibits 10-fold greater growth inhibition than olaparib against HR-deficient human cancer cell- or tissue-derived xenografts in nude mice. Solid Tumors Phase 1 Clinical |
| Name | Simmiparib |
|---|
| Description | Simmiparib is a novel potent, orally active PARP1/2 inhibitor with IC50 of 1.75/0.22 nM, inhibits PARP1 >90-fold more potently than the other PARPs (PARP3, TNKS1, TNKS2); selectively induces the accumulation of DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination repair (HR)-deficient cells; potentiates the proliferative inhibition of several conventional anticancer drugs, reduces the poly(ADP-ribose) formation in HR-deficient cancer cells and xenografts; exhibits 10-fold greater growth inhibition than olaparib against HR-deficient human cancer cell- or tissue-derived xenografts in nude mice. Solid Tumors Phase 1 Clinical |
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| References | References 1. Yuan B, et al. Cancer Lett. 2017 Feb 1;386:47-56. 2. Yang ZM, et al. Acta Pharmacol Sin. 2017 Jul;38(7):1038-1047. View Related Products by Target PARP Solid Tumors |
| Molecular Formula | C23H18F4N6O2 |
|---|---|
| Molecular Weight | 486.431 |