Homoarginine

Modify Date: 2024-01-02 13:08:45

Homoarginine Structure
Homoarginine structure
 Common Name Homoarginine
CAS Number 156-86-5 Molecular Weight 188.227
Density 1.4±0.1 g/cm3 Boiling Point 376.3±52.0 °C at 760 mmHg
Molecular Formula C7H16N4O2 Melting Point N/A
MSDS N/A Flash Point 181.4±30.7 °C

 Use of Homoarginine


H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

 Names

Name L-homoarginine
Synonym More Synonyms

 Homoarginine Biological Activity

Description H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.
Related Catalog
Target

Human Endogenous Metabolite

Alkaline phosphatase

In Vitro It is found that H-HoArg-OH (L-homoarginine), a homologue of arginine, is a strong inhibitor of human bone and liver alkaline phosphatase while it has virtually no effect on intestinal and placental alkaline phosphatases unlike H-HoArg-OH which inhibits intestinal and placental alkaline phosphatases but not the liver and bone enzymes. These four tissues mentioned are the major contributors to the serum alkaline phosphatase[1]. It is also indicated that low levels of the endogenous amino acid H-HoArg-OH are linked to cardiovascular disease[2].
References

[1]. Fishman W, et al. L-homoarginine; an inhibitor of serum "bone and liver" alkaline phosphatase. Clin Chim Acta. 1970 Aug;29(2):339-41.

[2]. Atzler D, et al. L-homoarginine and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):83-8.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 376.3±52.0 °C at 760 mmHg
Molecular Formula C7H16N4O2
Molecular Weight 188.227
Flash Point 181.4±30.7 °C
Exact Mass 188.127319
PSA 125.22000
LogP -1.86
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.587
Storage condition Store at RT.

 MSDS

Material Safety Data Sheet
Section1. Identification of the substance
Product Name: Homoarginine
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:Homoarginine
CAS number:156-86-5
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C7H16N4O2
Molecular weight:188.2
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL5550000
CHEMICAL NAME :
Lysine, N(sup 6)-amidino-, L-
CAS REGISTRY NUMBER :
156-86-5
LAST UPDATED :
199410
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H16-N4-O2
MOLECULAR WEIGHT :
188.27
WISWESSER LINE NOTATION :
QVYZ4MYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
44500 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,1072,1982

 Customs

HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

(S)-2-Amino-6-guanidinohexanoic acid
N6-(Aminoiminomethyl)-L-lysine
H-HOARG-OH
Homoarginine
MFCD00237108
L-Homoarginine
L-Lysine, N6- (aminoiminomethyl)-
N-Carbamimidoyl-L-lysine
N6-amidino-L-Lysine
N6-Carbamimidoyl-L-lysin
H-HAR-OH
L-Lysine, N-(aminoiminomethyl)-
H-HOMOARGININE
H-HOMOARG-OH
Homo-L-arginine
N6-carbamimidoyl-L-lysine
l-lysin
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