DBIBB
Modify Date: 2024-01-10 18:08:47
DBIBB structure
|
Common Name | DBIBB | ||
|---|---|---|---|---|
| CAS Number | 1569309-92-7 | Molecular Weight | 452.480 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 710.4±70.0 °C at 760 mmHg | |
| Molecular Formula | C23H20N2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 383.5±35.7 °C | |
Use of DBIBBA potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors; displays 33-fold increased potency over GRI977143; mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation and reduces apoptosis; enhances DNA repair by augmenting the resolution of γ-H2AX foci, increases clonogenic survival of irradiated IEC-6 cells, attenuates the radiation-induced death of human CD34(+) hematopoietic progenitors and enhances the survival of the granulocyte/macrophage lineage in mice. |
| Name | 2-{[4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]sulfamoyl}benzoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | A potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors; displays 33-fold increased potency over GRI977143; mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation and reduces apoptosis; enhances DNA repair by augmenting the resolution of γ-H2AX foci, increases clonogenic survival of irradiated IEC-6 cells, attenuates the radiation-induced death of human CD34(+) hematopoietic progenitors and enhances the survival of the granulocyte/macrophage lineage in mice. |
|---|---|
| References | References 1. Patil R, et al. Chem Biol. 2015 Feb 19;22(2):206-16. 2. Knowlden SA, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):402-9. View Related Products by Target Lysophospholipid Receptor |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 710.4±70.0 °C at 760 mmHg |
| Molecular Formula | C23H20N2O6S |
| Molecular Weight | 452.480 |
| Flash Point | 383.5±35.7 °C |
| Exact Mass | 452.104218 |
| LogP | 2.44 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.670 |
| 2-{[4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]sulfamoyl}benzoic acid |
| Benzoic acid, 2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]- |