STK899704
Modify Date: 2024-09-17 13:32:18
STK899704 structure
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Common Name | STK899704 | ||
|---|---|---|---|---|
| CAS Number | 1578247-29-6 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H23N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of STK899704A novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM; suppresses the growth of HeLa cells with IC50 of 350 nM, prevents the polymerization of purified tubulin in vitro and also depolymerizes microtubule in cultured cells leading to mitotic arrest, associated with increased Cdc25C phosphorylation and the accumulation of both cyclin B1 and Plk1 and apoptosis; shows anticancer activity in vivo. |
| Name | Ethyl (2-methyl-3-{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indol-1-yl)acetate |
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| Synonym | More Synonyms |
| Description | A novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM; suppresses the growth of HeLa cells with IC50 of 350 nM, prevents the polymerization of purified tubulin in vitro and also depolymerizes microtubule in cultured cells leading to mitotic arrest, associated with increased Cdc25C phosphorylation and the accumulation of both cyclin B1 and Plk1 and apoptosis; shows anticancer activity in vivo. |
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| References | References 1. Sakchaisri K, et al. PLoS One. 2017 Mar 15;12(3):e0173311. View Related Products by Target Microtubule/Tubulin |
| Molecular Formula | C27H23N3O4 |
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| Ethyl (2-methyl-3-{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indol-1-yl)acetate |
| 1H-Indole-1-acetic acid, 2-methyl-3-[(E)-[2-(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazinylidene]methyl]-, ethyl ester |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: STK899704
- Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: STK899704
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: STK899704
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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