Linsidomine hydrochloride

Modify Date: 2024-01-02 12:31:40

Linsidomine hydrochloride Structure
Linsidomine hydrochloride structure
Common Name Linsidomine hydrochloride
CAS Number 16142-27-1 Molecular Weight 206.630
Density N/A Boiling Point N/A
Molecular Formula C6H11ClN4O2 Melting Point 186 °C
MSDS Chinese USA Flash Point N/A

 Use of Linsidomine hydrochloride


SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits potent vasorelaxant effect and inhibition of platelet aggregation[1]. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[2].

 Names

Name 3-Morpholinosydnonimine hydrochloride
Synonym More Synonyms

 Linsidomine hydrochloride Biological Activity

Description SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits potent vasorelaxant effect and inhibition of platelet aggregation[1]. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[2].
Related Catalog
References

[1]. Nishikawa M,et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther. 1982 Jan;220(1):183-90.

[2]. Siegfried MR, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992 Feb;260(2):668-75.

 Chemical & Physical Properties

Melting Point 186 °C
Molecular Formula C6H11ClN4O2
Molecular Weight 206.630
Exact Mass 206.057053
PSA 67.28000
Storage condition -20°C
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WU7687800
CHEMICAL NAME :
Sydnone imine, 3-morpholino-, monohydrochloride
CAS REGISTRY NUMBER :
16142-27-1
LAST UPDATED :
198910
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H10-N4-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S24/25
RIDADR NONH for all modes of transport
HS Code 2934999090

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Comparative kinetics of thiol oxidation in two distinct free-radical generating systems: SIN-1 versus AAPH.

Free Radic. Res. 46(10) , 1190-200, (2012)

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 Synonyms

3-(4-morpholinyl)-5-sydnone imine hydrochloride
[3-(4-Morpholinyl)-1,2,3-oxadiazol-3-ium-5-yl]azanide hydrochloride (1:1)
3-(4-Morpholinyl)sydnone imine hydrochloride Linsidomine hydrochloride SIN-1 hydrochloride
T6N DOTJ A- AT5KNOYJ DUM &&sydnone
SIN-I HYDROCHLORIDE
LINSIDOMINE HCL
3-(4-morpholinyl)-sydnonimine hydrochloride
[3-(Morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-yl]azanide hydrochloride (1:1)
MFCD00221615
3-(4-Morpholinyl)sydnone imine hydrochloride
LinsidoMine Chlorhydrate
3-morpholinosydnone imine hydrochloride
1,2,3-Oxadiazolium, 5-amino-3-(4-morpholinyl)-, inner salt, hydrochloride (1:1)
MolsidoMine IMpurity A
SIN-1
SIN-1 CHLORIDE
B-HT 933 dihydrochloride
3-morpholino-sydnonimine hydrochloride
SIN-1 HCL
3-Morpholinosydnonimine hydrochloride
5-Imino-3-(morpholin-4-yl)-5H-1,2,3-oxadiazol-3-ium-2-ide hydrochloride (1:1)
SIN-1 HYDROCHLORIDE
EINECS 247-207-4
LINSIDOMINE
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