Acivicin hydrochloride

Modify Date: 2024-01-16 16:16:42

Acivicin hydrochloride structure	Common Name	Acivicin hydrochloride
	CAS Number	161922-40-3	Molecular Weight	215.03
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅H₈Cl₂N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Acivicin hydrochloride

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

Name	Acivicin hydrochloride

Description	Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
Target	γ−glutamyl transpeptidase[1]
In Vitro	Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1].
In Vivo	Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days; for 4 days) reduces urinary gamma-GT by 70-78%[1]. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[1] Dosage: 5 mg/kg Administration: IP; twice weekly (monday and wednesday); for 4 days Result: Reduced urinary gamma-GT by 70-78%.
References	[1]. Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition†Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26. [2]. Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5. [3]. Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30(3):154-60.

Molecular Formula	C₅H₈Cl₂N₂O₃
Molecular Weight	215.03

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Acivicin hydrochloride
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Acivicin hydrochloride
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Acivicin hydrochloride

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