tetrathiomolybdate

Modify Date: 2024-01-02 12:06:29

tetrathiomolybdate Structure
tetrathiomolybdate structure
Common Name tetrathiomolybdate
CAS Number 16330-92-0 Molecular Weight 224.22000
Density N/A Boiling Point N/A
Molecular Formula MoS4-- Melting Point N/A
MSDS N/A Flash Point N/A

 Use of tetrathiomolybdate


Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma[1][2][3].

 Names

Name tetrathiomolybdate(2−)

 tetrathiomolybdate Biological Activity

Description Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma[1][2][3].
Related Catalog
In Vivo Tetrathiomolybdate (0.2 mg/小鼠/天; 口服; 10 周)保护小鼠免受胶原诱导的关节炎,具有预防作用[1]。 Tetrathiomolybdate (0.03 mg/mL; 加在水中,8 周)通过减少肿胀和红斑抑制小鼠胶原诱导关节炎的进展[1]。 Animal Model: Collagen-induced arthritis model in mice[1] Dosage: 0.2 mg/mouse/day or 0.03 mg/mL, added in water Administration: Oral gavage, for 10 weeks; Collagen injected at weeks 2 Result: Showed significant preventive effect and protective effect in mice.
References

[1]. Zeng C, et al. Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes. Exp Biol Med (Maywood). 2008 Aug;233(8):1021-5.  

 Chemical & Physical Properties

Molecular Formula MoS4--
Molecular Weight 224.22000
Exact Mass 225.79400
PSA 64.18000
LogP 1.29160