Fosnetupitant chloride monohydrochloride

Modify Date: 2024-01-12 13:09:01

Fosnetupitant chloride monohydrochloride Structure
Fosnetupitant chloride monohydrochloride structure
 Common Name Fosnetupitant chloride monohydrochloride
CAS Number 1643757-72-5 Molecular Weight 761.52
Density N/A Boiling Point N/A
Molecular Formula C31H37Cl2F6N4O5P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fosnetupitant chloride monohydrochloride


Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an NK1 antagonist with pKi values of 9.5, 6.1 for human NK1 and NK3 receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant[1].

 Names

Name Fosnetupitant chloride monohydrochloride

 Fosnetupitant chloride monohydrochloride Biological Activity

Description Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an NK1 antagonist with pKi values of 9.5, 6.1 for human NK1 and NK3 receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant[1].
Related Catalog
Target

hNK1:9.5 (pKi)

hNK3:6.1 (pKi)

References

[1]. Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.  

 Chemical & Physical Properties

Molecular Formula C31H37Cl2F6N4O5P
Molecular Weight 761.52
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