19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a

Modify Date: 2024-01-08 10:35:25

19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a structure	Common Name	19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a
	CAS Number	16623-56-6	Molecular Weight	652.77600
	Density	1.175g/cm3	Boiling Point	739.9ºC at 760mmHg
	Molecular Formula	C₃₉H₄₄N₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	181.1ºC

Name	Thalidasine
Synonym	More Synonyms

Density	1.175g/cm3
Boiling Point	739.9ºC at 760mmHg
Molecular Formula	C₃₉H₄₄N₂O₇
Molecular Weight	652.77600
Flash Point	181.1ºC
Exact Mass	652.31500
PSA	71.09000
LogP	7.04680
Vapour Pressure	9.29E-22mmHg at 25°C
Index of Refraction	1.58

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XG2005000

CHEMICAL NAME :: Thalidasine

CAS REGISTRY NUMBER :: 16623-56-6

LAST UPDATED :: 199412

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C39-H44-N2-O7

MOLECULAR WEIGHT :: 652.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 11,217,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(7),46,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 mg/kg/7D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Related to Chronic Data - death

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 11,217,1980

O-methyl-thalfoetidine

O-Methylthalfetidine

6,6',7,7',12-Pentamethoxy-2,2'-dimethylthalidasan

Thalidasin

O-Methylthalfoetidin

O-methyl-thalrugosidine

Thalidusine,(S,S)

6,7,12,6',7'-pentamethoxy-2,2'-dimethyl-thalidasane